Placental corticotropin-releasing hormone: function and regulation

Article Abstract:

Corticotropin-releasing hormone (CRH) may regulate the induction of labor in humans. This hormone was first discovered in the hypothalamus, but it is also produced in the uterus and placenta. Levels of the hormone increase substantially in the last 6 to 8 weeks of pregnancy. CRH stimulates the fetal adrenal glands, leading to the production of corticosteroids that help the fetus mature. The fetal adrenal glands also produce a hormone that is coverted to estradiol. The increase in estradiol occurring at the end of pregnancy may initiate labor.

Physiological aspects, Corticotropin releasing hormone, Corticotropin-releasing hormone

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Saliva as a fluid for measurement of estriol levels

Article Abstract:

Saliva is an acceptable body fluid for measuring estriol levels. Estriol is a form of estrogen produced by the fetal adrenal glands. It crosses the placenta and appears in the mother's blood, urine, and saliva. Estriol levels begin to rise as a woman approaches delivery, which means estriol measurements can predict a woman's risk of premature delivery. An enzyme-linked immunosorbent assay (ELISA) has been developed to measure estriol in saliva samples. This will make it easy to test pregnant women who may be at risk of premature delivery.

Forecasts and trends, Measurement, Premature birth, Estrogen, Estrogens

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Changes in salivary estriol increases before parturition at term

Article Abstract:

The amount of estriol in the saliva of pregnant women begins to rapidly increase at week 35 and can be used to determine when the woman will go into labor, according to a study of 16 pregnant women. Estriol in the mother's body is actually produced from fetal hormones.

Parturition, Parturition (Animals)

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