Discontinuation of Chemoprophylaxis against Pneumocystis carinii Pneumonia in Patients with HIV Infection
Article Abstract:
Many HIV patients can stop taking drugs to prevent Pneumocystis carinii pneumonia (PCP) if aggressive treatment of their HIV infection has raised their CD4 T cell counts. Researchers analyzed the rate of PCP in 491 HIV patients with CD4 T cell counts greater than 200. None of the 146 patients who had stopped taking PCP preventive drugs developed PCP. These patients had higher T cell counts and lower viral levels than patients who continued taking the drugs.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2000
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Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease
Article Abstract:
Clarithromycin and rifabutin may be effective in preventing cryptosporidiosis in HIV patients. This infection with Cryptosporidium parvum affects 10% to 15% of HIV patients and can be fatal. Researchers collected data from 10 HIV clinics covering 1,019 HIV patients. Clarithromycin or rifabutin reduced the risk of cryptosporidiosis by 75% or more in these patients. The drug azithromycin had no effect on the incidence of cryptosporidiosis.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Pneumocystis carinii pneumonia incidence and chemoprophylaxis failure in ambulatory HIV-infected patients
Article Abstract:
Many HIV patients with advanced disease may develop Pneumocystis carinii pneumonia (PCP) even though they are taking drugs to prevent this opportunistic infection. In a study of 2,842 HIV patients, 1,582 were given drugs to prevent PCP. A total of 153 new cases of PCP occurred in these patients, and 67% of the new infections occurred in patients receiving drugs to prevent PCP. Patients with CD4+ T cell counts below 50 who had a history of PCP were most likely to develop PCP.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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