Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology
Article Abstract:
The severity of kidney disease in patients with systemic lupus erythematosus (SLE) may be evaluated by their blood levels of immunoglobulin G (IgG) antibodies to double stranded DNA (dsDNA). SLE is an inflammatory disorder that affects the connective tissues, the framework or structural fabric of the body. The blood levels of IgG and immunoglobulin M (IgM) antibodies to dsDNA and single-stranded DNA (ssDNA) was measured in 40 SLE patients. SLE patients with class IV kidney disease had significantly higher blood levels of IgG antibodies to dsDNA than those with class I, class II or class III kidney disease. Elevated blood levels of IgG were associated with an increased level of kidney damage. Blood levels of IgG antibodies to ssDNA or of IgM antibodies to ssDNA or dsDNA were not indicative of the severity of kidney disease.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
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Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus
Article Abstract:
The heart is often affected in children with systemic lupus erythematosus (SLE). This was the conclusion of a study of 31 children with SLE who had an echocardiogram. Thirteen children (42%) had some type of heart condition, usually an inflammation of the heart or the sac surrounding it. These conditions developed early, usually within six months of the diagnosis. They were also associated with autoantibodies such as anti-Ro/SS-A and anti-La/SS-B. These autoantibodies were much more common in the children with heart complications compared to those without.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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