Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside
Article Abstract:
Nucleosides are components of the genes of viruses such as the human immunodeficiency virus (HIV). If nucleoside analogues are substituted for nucleosides, they inhibit the growth and division of the virus. A very effective inhibitor of HIV is 3'-azido-2',3'-dideoxythymidine (AZT), which is used to treat patients with HIV infection and AIDS. 2',3'-dideoxyinosine (DDI) and 2',3'-dideoxy-2,6-diaminopurine riboside (ddDAPR) have been found to be effective inhibitors of the replication of HIV outside of the body, in tissue culture. However, when used in mice (as an animal model for HIV infections), they were only marginally effective in delaying disease. When used in combination with another drug, ribavirin, DDI and ddDAPR were much more effective both in tissue culture and in animals. These animal studies show the potential role of ribavirin, in combination with nucleoside analogues such as DDI, for treating patients with AIDS. Ribavirin has been found to be relatively safe and well tolerated, with a minimum of side effects in AIDS patients. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1990
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Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus
Article Abstract:
The drug FPMPA appears to be as effective in treating feline immunodeficiency virus (FIV) infection as the drug PMEA but without the serious side effects. FIV infection occurs in cats and produces a disease similar to human AIDS. This makes it a useful animal model for testing potential AIDS drugs. FPMPA and PMEA both inhibit the enzyme reverse transcriptase, which is produced by FIV as well as HIV. A study of 27 FIV-infected cats showed that FPMPA improved symptoms and lowered viral blood levels and was not toxic to bone marrow as PMEA often is.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in Rhesus macaques
Article Abstract:
A hybrid simian immunodeficiency virus (SIV) may allow researchers to use a monkey model of AIDs to test anti-HIV drugs. Most of these drugs inhibit the HIV viral enzyme reverse transcriptase (RT). However, they are not affective against SIV, which is a virus similar to HIV that affects monkeys. Researchers created a hybrid SIV by replacing SIV RT with HIV RT. Rhesus monkeys were infected with the hybrid virus and developed the symptoms of AIDS. The hybrid virus was sensitive to a group of AIDS drugs called nonnucleoside RT inhibitors.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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