Predominance of CCR5-dependent HIV-1 subtype E isolates in Cambodia
Article Abstract:
HIV subtype E that uses the CCR5 receptor appears to be predominate in Cambodia. The CCR5 cell receptor is a receptor on T cells that HIV uses to gain entry into the cell. A survey of 95 HIV-infected Cambodians showed that 89 were infected with subtype E. This subtype is traditionally transmitted via sexual intercourse. Viruses that used the CCR5 receptor were predominant and occurred in half of the patients with advanced disease.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1999
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Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women
Article Abstract:
HIV-1 can use different co-receptors to enter cells, according to a study of 42 HIV-infected women in Cameroon. Subtype A predominated and used CCR5 as a co-receptor. Fourteen percent of viral isolates used the orphan receptor Bonzo and some used both CCR5 and Bonzo.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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Increase of HIV-1 subtype A in Central African Republic
Article Abstract:
HIV-1 subtype A may be more infectious than other subtypes. In a study in Bangui, Central African Republic, the predominance of subtype A increased over a 10-year period, whereas the predominance of other subtypes remained the same.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
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