Plasma from preeclamptic women increases human endothelial cell prostacyclin production without changes in cellular enzyme activity or mass
Article Abstract:
The cells lining the umbilical cord appear to produce more prostacyclin when exposed to blood serum from preeclamptic women than when exposed to serum from healthy pregnant women. Prostacyclin dilates blood vessels and inhibits clotting. Blood samples were collected from preeclamptic and healthy women late in the third trimester and again a day or two after birth. Human umbilical cord lining cells suspended in culture medium were exposed to plasma extracted from these samples and the resultant amount of prostacyclin in the culture medium was measured. Amounts of prostacyclin were greater when the cells were exposed to plasma from preeclamptic women. Some suggestions as to possible mechanisms stimulating prostacyclin production were made.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: implications for oxidative stress
Article Abstract:
Changes in transferrin's ability to transport iron in the blood may affect the chemical processes involved in preeclampsia. Blood samples from 17 women with preeclampsia and 19 women with normal pregnancies were analyzed before and after delivery for iron binding capacity and iron and malondialdehyde levels. Transferrin levels and malondialdehyde interactions were also measured in a subgroup of samples. Women with preeclampsia had 98% higher iron saturation levels, 46% higher free iron levels, 50% higher malondialdehyde levels, and 14% lower iron-binding capacity. Iron-binding capacity corresponded to transferrin levels.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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- Abstracts: Preeclampsia: an endothelial cell disorder. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum
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