Pregnancy-induced elevation in aortic vascular smooth muscle actin in the Sprague-Dawley rat

Article Abstract:

The expression of smooth muscle alpha-actin may be greatly increased during pregnancy, indicating that pregnancy causes structural changes in arteries. Researchers obtained aortas from rats in late pregnancy and from non-pregnant rats and analyzed them for smooth muscle alpha-actin protein and messenger ribonucleic acid (mRNA). mRNA of smooth muscle alpha-actin was two times greater in aortas of pregnant rats. Pregnancy may structurally change arteries through increased blood flow and through blood and fluid changes. The contraction response of conduit arteries may increase in pregnancy, while reduced contractility may occur in peripheral arteries.

Measurement, Physiological aspects, Pregnancy, Actin, Smooth muscle, Aorta

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Obstetrical intervention rates and maternal and neonatal outcomes of women with gestational hypertension

Article Abstract:

Women who have hypertension during pregnancy are more likely to have longer labor, longer hospital stays, and a higher risk of operative delivery, postpartum hemorrhage, and neonatal intensive care use. This was the conclusion of a study of 12,765 pregnant women.

Health aspects, Hypertension in pregnancy, Gestational hypertension

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Conditioned medium from hypoxic cytotrophoblasts alters arterial function

Article Abstract:

Researchers provide evidence that fetal membranes in the placenta release substances that affect blood vessel function when the membranes are deprived of oxygen. This supports the hypothesis that preeclampsia is caused by abnormal development of the placenta.

Abnormalities, Causes of, Preeclampsia, Placenta

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