Myometrial arginase activity increases with advancing pregnancy in the guinea pig

Article Abstract:

The growth-inducing activity of arginase may be highest in the muscular wall of the pregnant uterus underneath the placenta. Researchers measured the level of arginase activity in uterine muscle tissues and kidneys from pregnant and nonpregnant guinea pigs. Arginase activity was twice as high in tissues from pregnant guinea pigs as from nonpregnant pigs, and was significantly higher in uterine muscle tissue from pregnant animals. The high activity was sustained through late pregnancy. The substance that activates arginase, perhaps interleukin-10 or interleukin-4, may circulate in the body but be most concentrated in the placenta. Arginase may function as a catalyst to provide the fetus with growth-inducing substances.

Measurement, Physiological aspects, Pregnancy, Myometrium, Arginase

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Encapsulated beta-islet cells as a bioartificial pancreas to treat insulin-dependent diabetes during pregnancy

Article Abstract:

Transplantation of coated pancreatic islet cells into pregnant diabetic mice appears to show promise as a pre-pregnancy option for correcting the mother's carbohydrate metabolism and preventing fetal deformities. Maternal weight and glucose levels and fetal deformity rates were compared among diabetic mice transplanted with islet cells and then bred, pregnant untreated diabetic mice, and normal pregnant mice. There was no significant difference between maternal blood glucose levels and weight among the transplanted diabetic mice and the normal mice. Only 1.4% of the pups with transplanted mothers had birth defects.

Care and treatment, Diabetes in pregnancy, Gestational diabetes, Pancreatic beta cells, Pancreatic beta cell transplantation

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