Epithelial ovarian tumors of low malignant potential
Article Abstract:
Epithelial ovarian tumors that do not invade the stroma (the connective tissue framework) have a low potential for malignancy. Factors indicating prognosis for patients with these types of tumors, other than stage of disease, are not clear. To further identify these factors, the records of 31 patients who had epithelial ovarian tumors were reviewed. Pathology data were analyzed for the stage and type of tumor for each patient. Follow-up data (median duration of 51 months) were also reviewed. Of the 31 patients, 23 had serous tumors and 6 had mucinous tumors. In 12 of the patients with serous tumors, bilateral ovarian tumors were present. Endometriosis was present in seven patients. The tumor was classified as stage I in 18 patients, stage II in 5, and stage III in 8. Of the two patients who died, one had a Stage II tumor and the other had a stage III tumor. These two patient had mucinous tumors and also had cancers outside the ovaries. When combined with data from a previous study, death rates for this type of cancer were 2 percent for stage I disease and 5 percent for stage III disease. Recurrence rates of the tumors ranged from 2 percent for stage I disease to 14 percent for stage III disease. Careful pathologic examination and staging of epithelial ovarian tumors are the most reliable factors for determining patient prognosis. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Obstetrics and Gynecology
Subject: Health
ISSN: 0029-7844
Year: 1991
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The prognostic significance of CA 125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction
Article Abstract:
CA 125, a carcinoembryonic antigen, is a protein found in the bloodstream that provides a measure of tumor malignancy. Its levels have been observed to be related with response to therapy for ovarian cancer. Therefore, CA 125 levels may correlate with patient prognosis. Previous studies suggested that the outcome of patients whose levels of CA 125 had half-lives of greater than 20 days (in other words, it took more than 20 days for levels to decrease by half) had a faster tumor growth and poorer outcome. The relationship between CA 125 levels and outcome was evaluated in 54 women with advanced ovarian cancer who were treated with surgery followed by chemotherapy. The survival rate of 38 patients with CA 125 half-life less than 20 days was significantly greater than that of remaining patients, with average survival approximately twice as long. Among patients who underwent surgical second-look procedures, those who were disease-free tended to have had CA 125 levels return to normal within 65 days of the initial surgery. However, this was not a significant effect, probably because of the small number studied. The study suggests that the half-life and level of CA 125 are somewhat predictive of ovarian cancer patients' response to chemotherapy, but further study is needed. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1990
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