Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis
Article Abstract:
The presence of autoantibodies to mitochondria with reactions to specific kinds of proteins characterizes primary biliary cirrhosis, a rare form of liver disease of unknown cause in which small bile ducts are destroyed. Current methods for the detection of antibodies to these proteins are either inadequate or unavailable. An enzyme-linked test to quantify specific antimitochondrial antibodies in patients with primary biliary cirrhosis was developed. The study shows that the levels of specific mitochondrial autoantibodies in the blood of patients with primary biliary cirrhosis can be quantified and monitored through the use of recombinant, cloned autoantigens.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1989
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Primary biliary cirrhosis
Article Abstract:
Primary biliary cirrhosis is a liver disease characterized by an autoimmune attack against cell mitochondria. This damages the small bile ducts in the liver. The disorder affects women primarily and is characterized by itching, fatigue, jaundice and an enlarged liver. A liver biopsy can confirm the diagnosis. Itching can be controlled with drugs that bind bile acids and ursodiol, colchicine and methotrexate are used to treat the underlying autoimmune disorder. The most effective treatment is a liver transplant.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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Primary biliary cirrhosis
Article Abstract:
The characteristics of primary biliary cirrhosis, which is described as a slow and progressive autoimmune disease, are presented. The autoimmune responses associated with this disorder, and their treatments are discussed in detail.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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