Pulmonary alveolar proteinosis - is host defense awry?

Article Abstract:

The investigation of effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies on neutrophil functions has shown that neutrophils from patients with pulmonary alveolar proteinosis have defects in both basal and GM-CSF-primed antimicrobial functions. It was found that patients with pulmonary alveolar proteinosis who had defective neutrophil function in vitro did not have increased neutrophil counts and serum G-CSF levels, suggesting that their host defense and innate immunity were sufficient for managing daily exposures to common pathogens and commensal organisms.

United States, Risk factors, Drug therapy, Disease/Disorder overview

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GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis

Article Abstract:

A study was conducted to test the hypothesis that neutrophil functions are impaired in patients with pulmonary alveolar proteinosis and that granulocyte-macro-phage colony-stimulating factor (GM-CSF) autoantibodies cause the dysfunction. It was found that the antimicrobial functions of neutrophils are impaired in patients with pulmonary alveolar proteinosis owing to the presence of GM-CSF autoantibodies.

Science & research, Research, Complications and side effects, Clinical report

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Pulmonary alveolar proteinosis

Article Abstract:

The physiology, diagnosis, and treatment of pulmonary alveolar proteinosis are reviewed. Topics include epidemiology, symptoms, X-ray findings, laboratory findings, natural history, surfactant homeostasis, mouse models, pathogenesis, and treatment. Pulmonary alveolar proteinosis is a rare lung disease caused by an accumulation of protein in the lungs.

Care and treatment, Diagnosis, Physiological aspects

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