Analysis of a large kindred with Blau syndrome for HLA, autoimmunity, and sarcoidosis

Article Abstract:

Familial granulomatous arthritis, uveitis and rash displays an autosomal-dominant transmission pattern and is manifested as various combinations of synovial cysts, arthritis, papuloerythematous rash and anterior and posterior uveitis. Known as the Blau syndrome, it was named for the researcher who first reported it. An attempt to determine whether HLA and autoimmunity played a role in the pathogenesis of the syndrome and whether it was related to sarcoidosis was made. Using 36 family members and spouses from a large kindred with Blau syndrome, 10 affected and many unaffected subjects were examined and their medical records and test results were reviewed. Four affected subjects, one possibly affected subject and one obligate carrier were found. Flexion contractures of fingers and toes were identified as a phenotype characteristic. Earlier onset and increasing severity of symptoms in succeeding generations were noted.

Development and progression, Genetic aspects, Autoimmunity, Familial diseases, Sarcoidosis

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Tropical pyomyositis (myositis tropicans): Current perspective

Article Abstract:

Tropical pyomyositis is a disease that is characterized by suppuration within skeletal muscles, and manifesting as single or multiple abscesses. Diagnosis techniques like ultrasound and computed tomography/magnetic resonance imaging are very useful in diagnosis.

United Kingdom, Science & research, Care and treatment, Research, Diagnosis, Magnetic resonance imaging, Myositis, Tomography

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