Recent infection with human immunodeficiency virus and possible rapid loss of CD4 T lymphocytes

Article Abstract:

HIV-infected patients who were infected recently may not have more infectious strains of the virus or deteriorate more quickly than patients who were infected near the beginning of the epidemic. Researchers studied three distinct groups of HIV-infected people and compared their CD4+ cell counts over time: 100 homosexual and bisexual men in San Francisco, Denver, and Chicago followed up since 1978, 89 people in South Carolina who acquired HIV after 1986, and 155 injection drug users in Baltimore followed up since 1988. CD4+ counts decreased rapidly in the year after HIV infection, then stabilized around 500 to 600 cells in all groups and in all years of infection. The theory that more infectious strains of HIV are present now than earlier in the epidemic cannot be proved.

Measurement, HIV (Viruses), HIV, CD4 lymphocytes

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Direct comparison of time to AIDS and infectious disease death between HIV seroconverter injection drug users (IDUs) in Italy and the United States: results from ALIVE and ISS studies

Article Abstract:

Use of injectible drugs does not seem to have a direct influnce on the rate of progression of the HIV infection as compared to individuals who do not use injectible drugs. Data was collected on 1,003 injection drug users (IDUs), of which 226 progressed to AIDS and 146 died after AIDS or from an infectious disease. The age of the individual was found to be important in estimating time of survival, but within each age group, there seemed to be no significant differences between gender, race, or time of seroconversion.

Health aspects, Physiological aspects, Drug abuse, Injections

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Reductions in high-risk drug use behaviors among participants in the Baltimore Needle Exchange Program

Article Abstract:

Needle exchange programs may be very effective in reducing risky behavior among drug addicts. Drug addicts participating in the Baltimore Needle Exchange Program reduced their use of used syringes and sharing used syringes with others. They also injected less often and had fewer injections per syringe.

Evaluation, Behavior, Drug addicts, Drug abusers, Needle exchange programs

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