Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

Article Abstract:

A chemical that blocks the insulin-like growth factor-1 (IGF-1) receptor prevents retinal angiogenesis. This demonstrates that IGF-1 regulates the production of vascular endothelial growth factor. It also explains why insulin therapy initially increases diabetic retinopathy.

Neovascularization, Insulin-like growth factor 1, Insulin-like growth factor I

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Directed vascular expression of the thromboxane A(sub)2 receptor results in intrauterine growth retardation

Article Abstract:

Increased thromboxane A(sub)2 synthesis may be responsible for intrauterine growth retardation. In a mouse model, overexpression of the thromboxane A(sub)2 receptor caused intrauterine growth retardation. Smoking and diabetes both increase thromboxane A(sub)2 biosynthesis.

Health aspects, Fetus, Fetal growth retardation, Thromboxanes

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The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection

Article Abstract:

Interleukin-12 and gamma interferon are involved in immunological tolerance of a foreign graft, according to a study in mice. Mice with deficient levels rejected a graft faster, as did those with defective B-cell development.

Research, Graft rejection, Interferon gamma, Interleukin-12

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