Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery

Article Abstract:

Urinary trypsin inhibitor appears to prevent preterm births in pregnant mice injected with a fat and carbohydrate compound of Escherichia coli. Researchers bred laboratory mice and injected the abdomens of pregnant mice with an E. coli fat and carbohydrate compound. Mice that were injected with two low doses of the compound all delivered fetuses preterm, and all of the fetuses were dead. This finding may explain why human pregnancies where mothers have an undetectable intrauterine infection may have high rates of preterm labor and delivery. Various drugs to inhibit preterm labor were used on the mice. Only urinary trypsin inhibitor effectively prevented preterm delivery, resulting in more live births of normal mice. Urinary trypsin inhibitor may increase the number of term deliveries in humans.

Premature birth, Trypsin inhibitors

---

Usefulness of a new tactile sensor for measurement of uterine cervical ripening in mice in a quantitative and noninvasive manner

Article Abstract:

A non-invasive technique for determining measurable changes in cervical ripening appears to be effective in mice. Researchers used a sensor to measure the cervical stiffness in pregnant, non-pregnant, and nursing mice. They also measured cervical stiffness in untreated pregnant mice in labor and pregnant mice treated with agents used to enhance cervical ripening. Measurements of cervical hardness decreased as pregnancy progressed and also in response to treatment with cervical ripening agents. These measurable changes in cervical texture coincided with observable changes.

Usage, Biosensors, Labor (Obstetrics), Cervix uteri, Mice as laboratory animals, House mouse, Incompetent cervix

---

Amniotic fluid lipopolysaccharide-binding protein and soluble CD14 as mediators of the inflammatory response in preterm labor

Article Abstract:

Lipopolysaccharide-binding protein and soluble CD14 macrophage receptor may cause inflammation in the uterus even when there are few bacteria present. This may explain why women in premature labor often have increased levels of inflammatory substances even when no microorganism can be isolated from amniotic fluid.

Infection, Inflammation, Inflammation mediators, Uterus

Similar abstracts:

• Abstracts: Recent trends in suicide and homicide among blacks. Television and violence: the scale of the problem and where to go from here
• Abstracts: The unseen menace: Thailand has thousands of street children - and every one of them risk slipping into prostitution and becoming just another statistic in an appalling AIDS epidemic
• Abstracts: Baby scoring system misses the point. Going straight to a new start in life: a new forensic psychiatric day care in Scotland staffed by nurses, provides ex-prisoners support and encouragement and has helped to cut rates of reoffending
• Abstracts: Use of chimeric human immunodeficiency virus types 1 and 2 reverse transcriptases for structure-function analysis and for mapping susceptibility to nonnucleoside inhibitors
• Abstracts: Combination therapy from a clinician's perspective. Absorption and elimination kinetics of zidovudine in the cerebrospinal fluid in HIV-1-infected patients

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.