Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
Article Abstract:
A randomized phase 1/2 study in lymphopenic individuals is performed after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. In the setting of lymphopenia, combined vaccine therapy and adoptive T-cell transfer fosters the development of enhanced memory T-cell responses.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
Article Abstract:
A study to show that inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity is presented. Stat3 signaling restrains natural tumor immune surveillance and inhibiting hematopoietic stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Article Abstract:
Tumor progression involves processes such as tissue invasion that can activate inflammatory responses, the immune system largely ignores or tolerates disseminated cancers. It is reported that constitutive activation of Stat-3 in tumor cells increases expression of proinflammatory mediators.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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