Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle

Article Abstract:

A study is conducted to evaluate the role of Na+/Ca2+ exchanger type 1 (NCX1) in salt-sensitive hypertension using SEA0400, a specific inhibitor of Ca2+ entry through NCX1, and genetically engineered mice. Results of the study reveal that salt-sensitive hypertension is triggered by Ca2+ entry through NCX1 in arterial smooth muscle and suggest that NCX1 inhibitors might be useful therapeutically.

All Other Basic Inorganic Chemical Manufacturing, Industrial inorganic chemicals, not elsewhere classified, Calcium, Calcium Supplements, Care and treatment, Hypertension, Influence, Calcium (Nutrient), Calcium, Dietary, Sodium in the body, Sodium (Nutrient), Cookery for hypertensives

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West Nile virus: Crossing the blood-brain barrier

Article Abstract:

The blood-brain barrier (BBB) prevents the pathogens from entering the brain but despite this barrier, some viruses such as the West Nile virus and Eastern equine encephalitis virus manage to gain access to the central nervous system (CNS). An improved understanding of the molecular signals that govern pathogen access to the CNS urge the development of therapeutics controls CNS entry.

Central Nervous System Prep, Risk factors, Central nervous system agents, Blood-brain barrier, West Nile virus

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Escherichia coli gets the message

Article Abstract:

Escherichia Coli Bacterial signaling systems have come into trend lately as an intermediate of successful interactions with the host. It is found that human hormones that are present in the gut interact with one such signaling system.

Hormones & Related Preparations, Hormone Preparations, Analysis, Escherichia coli, Bacterial infections, Hormones

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