Scedosporium inflatum: clinical spectrum of a newly recognized pathogen

Article Abstract:

Scedosporium inflatum is a newly identified pathogenic member of the dematiaceous (dark olive, grey or black) fungi. It differs from other members of the genus by its colonial morphology and the distinct character of its spore-bearing structures. Colonies are flat, spreading, olive-gray to black in color, and wooly textured. Other morphological characteristics and distinctions are described. Eleven case reports of S. inflatum infection are detailed and include clinical course, therapeutic intervention attempted, and outcome. They are believed to be the first reported cases of infection by this organism. Eight cases followed invasive S. inflatum infection and three cases followed colonization by the fungus, without firm evidence of invasiveness. Ten patients suffered penetrating trauma or underwent surgery prior to infection. A predisposition for fungal involvement of cartilage and joint areas was demonstrated. Infection in the case of an immunosuppressed patient had a fatal outcome. Resistance to amphotericin and other high potency antifungal agents was observed and some patients recovered without antifungal treatment. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Risk factors, Mycoses

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Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole

Article Abstract:

Taking oral fluconazole early in pregnancy does not appear to cause fetal anomalies. Short-term, low doses of fluconazole are prescribed to treat vaginal yeast infections. Researchers compared outcomes between 226 pregnant women who called a teratogen hotline because they had taken fluconazole and 452 women who called asking about exposure to harmless substances. Four percent of both groups had infants with anomalies. However, women exposed to fluconazole were five times more likely to have an abortion, suggesting fear may have led them to terminate the pregnancy. Prolonged, high doses cannot be assumed to be equally harmless.

Physiological aspects, Pregnancy

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In vitro susceptibility of clinical yeast isolates to fluconazole and terconazole

Article Abstract:

Terconazole may be more effective against yeast strains causing vaginal yeast infections than fluconazole. Researchers measured how much of each drug it took to inhibit yeast growth in cultures of 50 different strains of 5 species of yeast known to cause vaginal infections. Lower concentrations of terconazole than fluconazole were effective for all 5 species and each of the 50 strains. Studies have shown that results from this type of laboratory analysis can be correlated with response to treatment.

Drug therapy, Vaginitis

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