Serum Total Homocysteine Concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population Reference Ranges and Contribution of Vitamin Status to High Serum Concentrations
Article Abstract:
High homocysteine levels in the blood, which are associated with cardiovascular disease, seem to also be an accurate indicator of low levels of folate and vitamin B12. Blood was analyzed from 3,563 men and 4,523 women age 12 or over. The average ranges of homocysteine increased with the age of the subjects and, standards were set accordingly at 11.4 [micro]mol/L or over for men and 10.4 [micro]mol/L for women. After establishing normal standards for folate and vitamin B12, analysis showed that about two thirds of those individuals with high homocysteine levels also had low levels of vitamin concentrations.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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Nonfasting Plasma Total Homocysteine Level and Mortality in Middle-Aged and Elderly Men and Women in Jerusalem
Article Abstract:
A higher-than-average homocysteine level in blood plasma is a definite indicator of higher-than-average risk for death from all causes in people over 50 years of age. A high level has been seen to be related to cardiovascular disease in many studies. In analyzing nonfasting homocysteine levels of 1,788 participants over 50 with a nine to 11 year follow up, 25% of the men and 20% of the women were found to have high levels. Higher levels were associated with higher death rate for all causes except cancer, and this was especially so in the first five years of follow up.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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Treatment of hyperhomocysteinemia in renal transplant recipients: a randomized, placebo-controlled trial
Article Abstract:
Vitamin B6 supplements appear to help metabolize the elevated homocysteine levels seen in patients with kidney transplants. Decreases in homocysteine levels were compared in 29 patients with a kidney transplant after taking vitamin B6, vitamin B12 and folic acid, vitamins B6 and B12 and folic acid, or placebo. Homocysteine levels decreased by 22.1% in patients taking vitamin B6 in any combination and by 26.2% in patients taking vitamin B12 and folic acid in any combination.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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