Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
Article Abstract:
Mice with targeted deletion of the serum amyloid P component (SAP) gene have been shown to spontaneously develop antinuclear autoimmunity and severe glomerulonephritis, which resembles human system lupus erythematosus. SAP is the one normal circulating protein that shows specific calcium-dependent binding to DNA and chromatin in physiological conditions. Findings show that SAP has an important physiological role and inhibits the formation of pathogenic autoantibodies against chromatin and DNA, probably binding to chromatin and regulating its degradation
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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RNAi quashes polyQ
Article Abstract:
Short hairpin RNAs from an adeno-associated virus (AAV) vector was administered by injection into the brain of SCA1 transgenic mice, to express the polyglutamine disease, spinocerebellar ataxia type 1 (SCA1). This is revealed to be a new way for the clinical treatment of certain genetic disorders.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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From Agouti to Pomc -- 100 years of fat blonde mice
Article Abstract:
A mouse model of deficiencies in melanocortin production should help elucidate the genetic nature of these disorders. The mouse has a knockout gene for proopiomelanocortin (POMC), which is the precursor of melanocortin peptides as well as beta-endophin.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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