Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts
Article Abstract:
Iron appears to impede prostaglandin E2 (PGE2) production in synovial tissue, an important regulator of inflammation and damage in the arthritic joint. Researchers incubated synovial tissue samples from arthritis patient in solutions containing iron or a physiologically neutral medium. Synovial fibroblast tissue in iron citrate produced less PGE2 than fibroblasts in the neutral solution. PGE2 production increased when an iron-binding agent was added to the iron citrate solution. Inhibition of PGE2 production could reduce the inflammation of arthritis.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Hydroxychloroquine and visual screening in a rheumatology outpatient clinic
Article Abstract:
Evidence does not suggest the need for twice yearly comprehensive eye examinations for patients treated with low-dose hydroxychloroquine who have no evidence of eye abnormalities before treatment begins. Eye health was evaluated before hydroxychloroquine treatment was begun and twice yearly thereafter among 758 patients treated for various connective tissue disorders. The eye abnormalities found in only 12 of these patients were attributed to causes other than the drug treatment. No patients had damage to the retina.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Osteoarticular complications of brucellosis. Small intestinal mucosal protection mechanisms and their importance in rheumatology
- Abstracts: Can vitamin E protect humans against the pathological effects of ozone in smog? Consequences of severe copper deficiency are independent of dietary carbohydrate in young pigs
- Abstracts: Rice-based oral electrolyte solutions for the management of infantile diarrhea. Magnesium-induced diarrhea and new insights into the pathobiology of diarrhea
- Abstracts: Changes in body weight, body composition, and energy intake in women fed high- and low-fat diets
- Abstracts: HLA typing in families with multiple cases of rheumatoid arthritis. Microheterogeneity of alpha-1 acid glycoprotein in rheumatoid arthritis: dependent on disease duration?