Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity

Article Abstract:

Patients allergic to food have been reported to release much histamine form certain blood cells. (Histamine dilated the small capillary blood vessels, lower blood pressure, causes contraction of certain muscles, increases the stomach's secretion of fluid and accelerated the heartbeat). Sixty-three patients were evaluated to determine whether patients with skin inflammation due to a food allergy have high rated of histamine release from certain blood cells (when their cells are trested in the laboratory). Whether elimination from the diet of the allergic foods affects histamine release and whether the release could be accounted for by a cytokine known to stimulate release of histamine were studied. Thirty-eight of the patients had eliminated the allergic foods from their diets, twenty had skin inflammation (atopic dermatitis) due to non-food allergies, and eighteen were normal. Patients with atopic dermatitis were found to have higher rates of histamine release. Patients who had eliminated the offending food from the diet for an extended period of time had a significantly lower rate of histamine release. Patients with atopic dermatitis due to a non- food allergy had normal rates of histamine release. Certain cells from food allergy patients produced a chemical that stimulated the release of histamine from certain blood cells of other food allergy patients, but not from the blood cells of normal people. Allergic patients on restricted diets produced less of this chemical stimulator. Thus in patients with food allergies an abnormality of the disease-fighting immune system makes a chemical stimulator trigger histamine release.

Physiological aspects, Histamine, Food allergy, Food hypersensitivity, Basophils

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Sleep disturbances in children with atopic dermatitis

Article Abstract:

The itching and scratching associated with atopic dermatitis (AD) may interfere with children's sleep and may cause fatigue-related daytime behavioral problems. AD is an extremely itchy, chronic skin inflammation that affects allergy-prone people. Researchers surveyed the parents of 59 children with AD to study the children's sleep behavior, AD symptoms, and daytime behavior. Children with AD had greater difficulty falling asleep, more restless sleep, more frequent waking during the night, greater difficulty waking up in the morning, and obtained fewer total hours of sleep than normal children. The severity of AD symptoms was significantly related to sleep problems. AD-induced itching and scratching that caused night awakening was associated with difficulty staying awake during the day and with major discipline problems.

Behavior disorders in children, Childhood mental disorders

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Sleep Fragmentation in Children With Atopic Dermatitis

Article Abstract:

Atopic dermatitis in children may disturb their sleep, but most awakenings do not appear to be caused by scratching. Atopic dermatitis is an itchy skin rash relatively common in small children. Researchers compared the effects of scratching in 14 children with dermatitis and nine healthy children. Children with atopic dermatitis awakened or became aroused an average of 24 times per hour, while the children without dermatitis became aroused only 15 times per hour. Episodes of skin scratching were only associated with 15% of the arousals.

United States, Pruritus, Itching

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