Statins as a newly recognized type of immunomodulator

Article Abstract:

Statins were found to directly inhibit induction of major histocompatibility complex class II (MHC-II) expression via interferon gamma (IFN-gamma), and thereby act as repressors of T-cell activation mediated by MHC-II. Implications for the use of statins as immunosuppressors in organ transplantation and other pathologies are discussed.

Switzerland, Statistical Data Included, Research, Immunosuppression

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Immunomodulation: a new role for statins?

Article Abstract:

Research indicates that chronic inflammatory diseases may be successfully treated with statins, which inhibit the expression of the class II major histocompatibility complex (MHCII). This leads to a reduction in T-cell response, suggesting that conditions such as graft atherosclerosis can be affected by this process.

Inflammation, Inflammation mediators

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Statins: lower lipids and better bones?

Article Abstract:

Research presented concerns the use of statins, agents found in cholesterol-lowering drugs, to stimulate bone formation. The physiological aspects of the interaction between osteoblasts and statins are described, and the implications for osteoporosis sufferers are examined.

Drug therapy, Bone diseases, Osteoporosis, Osteoblasts

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