Subcutaneous interferon alpha in the treatment of refractory condylomata

Article Abstract:

Condylomata acuminata, or genital warts, is the most common sexually transmitted disease of viral origin. It is caused by human papillomavirus, and the lesions are frequently unresponsive to treatment; response to treatment is usually only for a short duration. Interferon, proteins formed in response to foreign agents and are important in immune function, are known to have antiviral and antiproliferative properties. was studied for the treatment of genital warts. Fifteen women with genital warts that unresponsive to treatment were given interferon therapy. Interferon was administered subcutaneously three times a week, with a total of 10 injections. The dosage was three million IU (international units) of interferon alpha-2a. Responses were variable at 14 percent remission at two weeks; 27 percent at one month; and 36 percent at three months. Abnormal cervical cytology correlated with poor response. Adverse effects from the interferon were mild. Further studies with interferon alpha are warranted, especially as an adjuvant to other treatment protocols. (Consumer Summary produced by Reliance Medical Information, Inc.)

Care and treatment, Drug therapy, Condyloma acuminatum, Genital warts, Interferon alpha

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First-void urine testing for Chlamydia trachomatis by polymerase chain reaction in asymptomatic women

Article Abstract:

A urine test appears to be a simple and accurate screening test for chlamydia. Urine and cervical swab tests for chlamydia were performed on 1,090 women with no indications of a chlamydia infection. Overall, 5.6% of these women were found to have previously undetected chlamydia infections. The urine test successfully identified 85% of these infected women while the cervical swab test correctly identified 90%. Test results were confirmed with an antibody test if one result was positive and one negative.

Analysis, Diagnosis, Polymerase chain reaction, Chlamydia infections, Urine, Urinalysis

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Rapid decrease of endemic gonorrhea in Finland

Article Abstract:

The incidence of gonorrhea in Finland has dropped significantly since 1990. Analysis of data from sexually transmitted disease clinics in Helsinki between 1990 and 1995 show that gonorrhea represented 3.3% of all patient visits in 1990, 1.3% in 1992-93 and 0.9% in 1994-95. This was due to a drop in the number of endemic cases, whereas the number of imported cases of gonorrhea remained constant during this period. There was no obvious explanation for the drop in endemic gonorrhea.

Finland, Statistics, Gonorrhea

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