Successful treatment of relapse of acute promyelocytic leukemia with a new synthetic retinoid, Am80
Article Abstract:
Treatment with the synthetic retinoid Am80 may be effective in treating patients with recurring symptoms of promyelocytic leukemia previously treated with all-trans retinoic acid (ATRA). Doctors treated two patients with Am80 after symptoms of promyelocytic leukemia reappeared following successful treatment with ATRA. Genetic and bone marrow testing confirmed that the patients once again had promyelocytic leukemia as indicated by the percentage of abnormal white blood cells called promyelocytes. Bone marrow testing following treatment with Am80 confirmed that there were no promyelocytes present in either patient. Other blood counts in both patients gradually returned to normal levels as well. Both patients received bone marrow transplants following treatment. The only reported side effects of this treatment were elevated cholesterol and blood fat levels easily controlled with medication.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Complete remissions in hairy cells leukemia with 2-chlorodeoxyadenosine after failure with 2'-deoxycoformycin
Article Abstract:
Treatment with 2-chlorodeoxyadenosine (2-CdA) may be an effective treatment for hairy cell leukemia in patients who do not respond or are intolerant of treatment with 2'-deoxycoformycin (DCF). Hairy cell leukemia is a rare form of leukemia that affects B-cells. Among five patients with hairy cell leukemia who were treated with intravenous 2-CdA, three had been resistant to treatment with DCF and two had had life-threatening toxic reactions to DCF. Four patients had a complete response to treatment with 2-CdA, and one had a partial response. A complete response occurred in both of the patients who had been intolerant of treatment with DCF. Three patients who had a complete response were still in remission more than eleven months after treatment. The patient who had a partial response died after developing a blood infection.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1993
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Abnormal heart rhythm in patients with leukemia treated with arsenic trioxide
Article Abstract:
Arsenic trioxide may cause abnormal heart rhythms, according to a study of eight patients. Arsenic trioxide is used to treat a type of cancer called promyelocytic leukemia. Cancer patients who take arsenic trioxide should have their heart activity monitored.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2000
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