Synovial perfusion and synovial fluid solutes
Article Abstract:
The study of synovial perfusion, or blood flow in the joint cavity, provides information about the joint inflammation common to arthritis. Synovium refers to the membrane which lines the cavity of a joint. Synovial perfusion can be measured in absolute terms using radiolabelled microspheres to study blood flow through arteries and joint clearance of radiolabelled markers. Laser Doppler, ultrasound, and magnetic resonance imaging can be used to measure relative differences in blood flow. Radiolabelled substances injected into a joint are used as markers to measure the rate of clearance of the substances. The protein, albumin, can be radiolabelled and used as a marker of perfusion in the joint cavity. Markers have been used to determine the rate of clearance of non-steroidal anti-inflammatory drugs (NSAIDs) through a joint.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Towards a coherent terminology of gout
Article Abstract:
A more systematic terminology may need to be developed for gout. Gout is a group of disorders of purine and pyridimine metabolism. Fully developed gout is characterized by deposition of crystals around the joints of extremities. Among 26 rheumatologists with a special interest in gout, 17 thought that better terminology should be developed for crystal deposition states and their associated syndromes. Several problems exist with the present terminology. One is that the term gout has different meanings to different individuals. This problem could solved by using the term gout for any type of crystal deposition in the joints. Another problem is that certain disease-causing crystals are referred to by different names. There are also no accepted guidelines for naming crystal deposition problems.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Effect of synovial fluid hyaluronan on the clearance of albumin from the canine knee
Article Abstract:
Hyaluronan, a component of synovial fluid, may not influence the turnover of albumin through the fluid. Synovial fluid is the fluid within a joint, surrounded by a membrane of synovium which lines the joint. Researchers studied the effect of hyaluronan on the movement of albumin in the blood through the knee joints of dogs. They concluded that hyaluronan may decrease the turnover of albumin in knees that have lost too much fluid, but that hyaluronan does not affect albumin clearance in normal joints. People with osteoarthritis or inflamed joints have lower than normal levels of hyaluronan in the joint fluid, and decreased molecular mass of hyaluronan. Movement of albumin or other substances through diseased joints may be influenced more by lack of fluid or inflammation than by hyaluronan.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis. Urinary and synovial pyridinium crosslink concentrations in patients with rheumatoid arthritis and osteoarthritis
- Abstracts: An economic evaluation of asthma in the United States. Tetanus - forgotten but not gone. A population-based serologic survey of immunity to tetanus in the United States
- Abstracts: Managed care and quality. The past, present, and future of nursing home quality. End-stage renal disease core indicators project
- Abstracts: The mother of fevers. The Global Malaria Control Strategy. Malaria: hope for the future
- Abstracts: Improving the quality of long-term care. Addressing the ethical, legal, and social issues raised by voting by persons with dementia