Ibuprofen, inflammation and alzheimer disease

Article Abstract:

This article examines the relationship between non-steroidal anti-inflammatory drugs and alzheimer disease in the light of a recent finding that they restict Alzheimer disease type pathology. Research reveals that transgenic mice treated with ibuprofen show significant reductions in the cerebral amyloid deposition.

Analysis, Usage, Physiological aspects, Drug therapy, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Amyloidosis, Ibuprofen, Anti-Alzheimer's disease agents

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TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice

Article Abstract:

Research presented concerns the factors responsible for the over-accumulation of amyloid beta-protein in the brain, a process that characterizes Alzheimer's disease. Topics include the molecular biology of transgenic mice, focusing on the role of transforming growth factor beta 1 on the deposition of amyloid beta proteins.

Statistical Data Included, Research, Transforming growth factors, Amyloid beta-protein, Genetically modified mice, Brain diseases

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

Article Abstract:

Inflammation is proposed as a possible cause or driving force of Alzheimer disease, but it is necessary to determine whether inflammation is an early event, whether it is genetically linked with the disease and whether manipulation of inflammatory pathways changes the course of the pathology. Increasing evidence from mouse models suggests that certain inflammatory mediators are potent drivers of the disease, but related factors, on the other hand can trigger beneficial responses and can reduce the disease.

Causes of, Complications and side effects, Genetic aspects, Inflammation

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