Targeting specific cell types with silencing RNA
Article Abstract:
Details of the procedure to deliver small double-stranded particles of RNA called short interfering RNA (siRNA) to certain cellular or tissue targets are presented. The resolution of specific issues related to this procedure not only makes siRNA a fundamental research tool, but renders it highly useful for drug-target validation.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Targeting specific cell types with silencing RNA
Article Abstract:
Details of the procedure to deliver small double-stranded particles of RNA called short interfering RNA (siRNA) to certain cellular or tissue targets are presented. The resolution of specific issues related to this procedure not only makes siRNA a fundamental research tool, but renders it highly useful for drug-target validation.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Small RNAs and large DNA viruses
Article Abstract:
The human cytomegalovirus (CMV) generates noncoding RNAs that allow viruses to persist by enhancing the survival of infected cells and shielding them from attack by natural killer cells. CMV uses a noncoding RNA to optimize the cellular environment for viral infection.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Safety tips. When to use fall arrests with scissor lifts
- Abstracts: Follow-up testing among children with elevated screening blood lead levels. Effect of intensive handwashing promotion on childhood diarrhea in high-risk communities in Pakistan
- Abstracts: Using clinical guidelines designed for older adults with diabetes mellitus and complex health status
- Abstracts: Progressive prothrombotic state in women with advancing HIV disease. T-cell lymphoma in HIV-infected patients
- Abstracts: Placental sulfatase deficiency and congenital ichthyosis with intrauterine fetal death: case report