The Preterm Prediction Study: association between cervical interleukin 6 concentration and spontaneous preterm birth

Article Abstract:

A positive test for fetal fibronectin and increased levels of interleukin-6 in cervical fluid at 24 weeks' gestation may identify pregnant women who will deliver prematurely. This was the conclusion of a study of 125 pregnant women who delivered prematurely and 125 who delivered at term.

Fibronectins, Premature birth, Interleukin-6

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Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy

Article Abstract:

The frequency of inflammatory cytokine and Toll-like receptor gene polymorphisms in women with and without bacterial vaginosis (BV) in pregnancy is estimated. Results conclude that after controlling for race, polymorphisms at the interleukin (IL) 1beta Exon 5 + 3954, IL6-174, and IL8-845 loci are associated with an altered rate of BV in pregnancy.

United States, Science & research, Research, Genetic aspects, Vaginosis, Genetic polymorphisms, Cytokines, Pregnancy, Complications of, Pregnancy complications, Bacterial vaginosis

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The Preterm Prediction Study: failure of midtrimester cervical sialidase level elevation to predict subsequent spontaneous preterm birth

Article Abstract:

Elevated levels of sialidase in cervical secretions do not appear to predict premature birth. Sialidase is an enzyme produced by certain bacteria. Premature birth is thought to be caused by a uterine infection. Researchers measured sialidase levels in cervical and vaginal smears taken from 126 women in premature labor and 126 women. Sialidase levels were similar in both groups.

Enzymes, Premature labor

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