The SPICE study: 48-week activity of combinations of saquinavir soft gelatin and nelfinavir with and without nucleoside analogues
Article Abstract:
Quadruple therapy with saquinavir, nelfinavir and two nucleoside reverse transcriptase inhibitors appears to be more effective in treating HIV infection than triple therapy with only one protease inhibitors. Nelfinavir inhibits an enzyme that metabolizes protease inhibitors, leading to increased blood levels of the drug.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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Long-term follow-up of antiretroviral-naive HIV-positive patients treated with nevirapine
Article Abstract:
The AIDS drug nevirapine appears to be effective in patients who have not taken any AIDS drugs, according to a study of 125 patients. However, after two years of treatment, 37 patients had an increase in viral levels that had been low on at least one occasion.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Steady state pharmacokinetics of saquinavir hard-gel/ritonavir/fosamprenavir in HIV-1-infected patients
Article Abstract:
The evaluation of steady-state pharmacokinetics of saquinavir 1000mg twice daily and fosamprenavir 700mg bid administered with 2 different doses of ritonavir in HIV-1-infected subjects is done. The coadministration of these resulted in statistically nonsignificant decrease in saquinavir exposure compared with baseline.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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