The changing approach to the treatment of early breast cancer

Article Abstract:

It appears that chemotherapy before radiation treatment in early-stage breast cancer may prolong life without significantly increasing local recurrence of cancer. Until the 1970s, the treatment for breast cancer consisted of mastectomy followed by radiotherapy. This was challenged when researchers discovered that surgery followed by chemotherapy could eliminate the need for radiotherapy. This has become even more important now that many younger women are being diagnosed with early-stage cancer and are being treated with a lumpectomy. A 1996 study found that lumpectomy followed by chemotherapy resulted in improved survival rates compared to women who had a lumpectomy followed by radiotherapy. However, the study was relatively small and many of the women were not representative of most women who develop breast cancer. But two other studies have confirmed that radiotherapy can be delayed until the completion of chemotherapy.

Breast cancer, Radiotherapy

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Limiting therapy for limited childhood non-Hodgkin's lymphoma

Article Abstract:

Children with non-Hodgkin's lymphoma who have early-stage disease and a good prognosis may be cured with minimal chemotherapy. Up until the 1940's, the only treatments for most cancers were surgery and radiation therapy. When chemotherapy was introduced, it quickly became the most effective treatment for childhood lymphoma, leading to cure rates of 80% to 90%. However, radiation and chemotherapy have serious side effects, especially in young children. A 1997 study found that a short course of chemotherapy was just as effective as a long course. However, patients with a worse prognosis may need longer treatment.

Cancer in children, Childhood cancer, Non-Hodgkin's lymphomas

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High-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors

Article Abstract:

A study examines the efficacy of high-dose chemotherapy and rescue of the hematopoietic system of infusion of peripheral-blood stem cells for cisplatin-resistant, progressively growing testicular cancer. Findings suggest that the treatment is successful even when used as third-line or later therapy or in patients with platinum-refractory disease.

Germ cell tumors, Germinoma, Drug therapy, Cancer, Testicular cancer, Clinical report

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