The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants

Article Abstract:

Giving pregnant women in premature labor phenobarbital just prior to delivery does not appear to reduce the risk of intracranial hemorrhage in the baby. Researchers gave phenobarbital or a placebo intravenously to 610 women who were in premature labor and expected to deliver within 24 hours. They continued to receive oral phenobarbital once a day if they did not deliver within 24 hours. Ultrasound scans of the baby following its birth revealed that intracranial hemorrhage occurred in 23% of the infants in both groups. Phenobarbital also did not reduce infant mortality.

Usage, Brain, Hemorrhage, Brain hemorrhage, Phenobarbital

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Vitamin A supplementation for extremely-low-birth-weight infants

Article Abstract:

Intramuscular injections of vitamin A three times a week for several weeks appears to improve lung function in extremely-low-birth-weight babies. These infants have a high risk of lung diseases caused by extreme prematurity. Researchers randomly assigned 807 such infants to receive intramuscular shots of vitamin A or a placebo. Only 55% of the infants who received vitamin A died or developed lung disease compared to 62% of those who received placebo.

Care and treatment, Birth weight, Low, Low birth weight, Lung diseases, Vitamin A

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Inhaled nitric oxide for premature infants with severe respiratory failure

Article Abstract:

A multicenter, randomized, blinded, controlled trial is conducted to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in premature infants with severe respiratory failure. The results reveal that the use of inhaled nitric oxide in critically ill premature infants weighing less than 1500 g does not decrease the rates of death or bronchopulmonary dysplasia.

United Kingdom, Drug therapy, Dosage and administration, Inhaled medication, Bronchopulmonary dysplasia

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