The effect of debulking surgery after induction chemotherapy on the prognosis in advanced epithelial ovarian cancer

Article Abstract:

Debulking surgery to reduce the size of an ovarian tumor may improve survival rates. This type of surgery is often done to make the tumor more sensitive to chemotherapy. A total of 278 women with ovarian tumors greater than one centimeter (cm) received three cycles of chemotherapy with cyclophosphamide and cisplatin. Then 140 received debulking surgery within a month of chemotherapy and 138 did not. Four weeks after surgery, all the women received an additional three cycles of chemotherapy. Women who received debulking surgery survived several months longer on average than the women who did not have surgery. Two years after treatment, 56% of the women who had debulking surgery were alive, compared to 46% of the women who did not have surgery. Women who had tumors smaller than one cm. before debulking surgery lived longer than those whose tumors were larger than one cm. Nevertheless, all women who had debulking surgery benefitted from the treatment.

Ovarian cancer

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Surgery to reduce lung volume

Article Abstract:

Several mechanisms probably help the lungs of patients with emphysema to function better after lung-reduction surgery. Emphysema is a lung disease characterized by the thinning and loss of elasticity of lung tissue. A 1996 study found patients improved markedly after lung-reduction surgery, the removal of at least 25% of damaged lung tissue. Breathing difficulties were thought to improve because of the increased elastic recoil of the lung after surgery. Two other physiological systems within the thorax, the muscles of respiration and the cardiovascular system, may be involved. The enlarged lung causes over-inflation and flattens the diaphragm, progressively shortening the muscles and defeating inhalation efforts. Surgery effectively restores the chest's ability to inhale and expand outward. Similarly, surgery restores the cardiac output compromised otherwise during exercise, by improving the volume of venous return.

Editorial, Prevention, Physiological aspects, Lungs, Physiological regulation, Respiration, Emphysema, Pulmonary, Emphysema, Shortness of breath, Dyspnea, Lung surgery

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