The effect of spironolactone on morbidity and mortality in patients with severe heart failure

Article Abstract:

Spironolactone appears to be effective in lowering mortality rates of patients with severe heart failure. This drug blocks the hormone aldosterone, which can sometimes make heart failure worse. Researchers randomly assigned 1,663 patients with severe heart failure to take spironolactone or a placebo every day for up to two years. The death rate in the spironolactone group was 30% less than in the placebo group. The spironolactone group also had fewer symptoms of heart failure and 35% lower hospitalization rates. Breast pain was the most common side effect of the drug.

Statistical Data Included, Heart failure, Spironolactone

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Cancer-associated thrombosis

Article Abstract:

A group of drugs called low-molecular-weight heparins should be given to all cancer patients who have abnormal blood clotting. Cancer cells can cause abnormal blood clot formation, and so can chemotherapy drugs and the intravenous catheters used to administer chemotherapy. A study published in 2003 showed that the drug Fragmin, a low-molecular-weight heparin, can reduce the risk of abnormal blood clotting without substantially increasing the risk of bleeding.

Product/Service Evaluation, Prevention, Causes of, Complications and side effects, Cancer, Thrombosis, Blood clot, Fragmin (Medication)

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Eplerenone, a selective aldosterone blocker, in patinets with left ventricular dysfunction after myocardial infarction

Article Abstract:

The drug eplerenone may be beneficial for patients who have had a heart attack that develops into heart failure, according to a study of over 6,000 patients. The patients who took the drug had a 15% lower mortality rate over an average of 16 months than those who took a placebo, or inactive substance. The drug also lowered the risk of sudden death.

Heart attack

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