The effects of oligohydramnios and cervical cord transection on lung growth in experimental pulmonary hypoplasia in rabbits

Article Abstract:

Amniotic fluid volumes and breathing movements in the uterus appear to produce different effects on lung development in rabbits. Researchers cut the spinal cords of 12 fetal rabbits to stop fetal breathing (transection group) and diverted amniotic fluid into the mothers in an additional 12 fetal rabbits (shunt group). Lung development and surfactant production were compared after birth with 12 healthy fetal rabbits (control group). Lung development was significantly diminished in the transection group compared to the shunt and control groups. Surfactant production was highest in the shunt group.

Physiological aspects, Growth, Oligohydramnios

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Diagnosis of fetal pulmonary hypoplasia by measurement of blood flow velocity waveforms of pulmonary arteries with Doppler ultrasonography

Article Abstract:

Doppler ultrasound can be effective in detecting fetal pulmonary hypoplasia. This condition is characterized by underdevelopment of the lungs and can be fatal. Researchers used Doppler ultrasound prenatally on 300 pregnant women between 24 and 40 weeks' gestation. A measurement of blood flow called the pulsatility index decreased in healthy fetuses as pregnancy advanced, but remained high in those with fetal pulmonary hypoplasia. Another measurement called peak systolic velocity increased in healthy fetuses as pregnancy advanced but remained low in those with fetal pulmonary hypoplasia.

Blood flow, Diagnosis, Measurement, Blood flow measurement, Medical examination, Lung diseases, Doppler ultrasonography

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Ultrasonographic prediction of lethal pulmonary hypoplasia: comparison of eight different ultrasonographic parameters

Article Abstract:

Lung ultrasound measurements appear to be useful in predicting which fetuses will have underdeveloped lungs. Eight measurements were made on ultrasound scans from 21 pregnancies at risk for underdeveloped lungs and were compared with the same measurements made on 150 normal pregnancies. Measurements of lung surface area and the ratio of chest to abdomen circumference were highly predictive of lung underdevelopment. Other significant correlations were found between lung weight and lung weight to body weight ratios and the risk for underdeveloped lungs.

Methods, Evaluation, Abnormalities, Prenatal diagnosis, Diagnosis, Ultrasonic, Diagnostic ultrasonography

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