The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma
Article Abstract:
Injections of human chorionic gonadotropin into Kaposi's sarcoma lesions appear to be effective in treating this disease. Kaposi's sarcoma isn a skin tumor that often occurs in AIDS patients. Researchers injected different doses of a human chorionic gonadotropin called A.P.L. into the skin lesions of 36 AIDS patients with Kaposi's sarcoma. The higher the dose, the more complete the tumor regression. Microscopic examination of the skin tumors revealed evidence of a natural type of cell death called apoptosis. There was no evidence of an immune response against the tumors.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines
Article Abstract:
The role of human herpesvirus 8 (HHV-8) in Kaposi's sarcoma is not clear. Kaposi's sarcoma is a skin tumor that occurs in many HIV-infected people. The virus, which is also called Kaposi's sarcoma herpesvirus (KSHV), was first identified in blood cells of AIDS patients with Kaposi's sarcoma in 1994. It occurred in 90% of Kaposi's sarcoma tissue samples but only 15% of normal tissue samples. Researchers studying a malignant Kaposi's sarcoma cell line found no evidence of HHV-8. However, the virus was found in many different types of CD lymphocytes.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Kaposi's sarcoma - what's human chorionic gonadotropin got to do with it?
Article Abstract:
It is not clear how human chorionic gonadotropin causes Kaposi's sarcoma lesions to regress. A 1996 study showed that injecting human chorionic gonadotropin into skin lesions of patients with Kaposi's sarcoma led to a regression of the lesions. This treatment may not be practical, however, because many AIDS patients have dozens and even hundreds of lesions. Any dose of human chorionic gonadotropin that could be taken orally would be extremely expensive. Research also shows that human chorionic gonadotropin may not be the active compound.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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