The effects of weight loss on activity and expression of adipose-tissue lipoprotein lipase in very obese humans
Article Abstract:
Many aspects of obesity, including the behavioral and genetic factors involved, have been studied extensively. But the physiologic process by which the body stores fat tissue has not yet been fully described. An important enzyme involved is lipoprotein lipase, which transforms the fat that is eaten into stored adipose tissue. For this reason, lipoprotein lipase has been called the ''gatekeeper of the adipocyte'' (adipocytes are body fat cells). The activity of enzymes such as lipoprotein lipase is regulated by the body and may be adjusted under certain conditions. A study was performed to determine whether lipoprotein lipase activity is affected by weight loss in obese persons. Nine severely obese subjects were tested for lipoprotein lipase activity in the fat cells before and after losing weight. The subjects lost an average of 94 pounds by following a very-low-calorie diet. A significant increase in the activity and expression of lipoprotein lipase occurred with this substantial weight loss. It appears likely that this increased enzyme activity would favor further storage of fat and make it more difficult to lose additional weight. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1990
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Inhibition of food intake in obese subjects by peptide YY(sub 3-36)
Article Abstract:
A deficiency of a substance called peptide YY(sub 3-36) in the body may be one cause of obesity, according to a study of 12 obese and 12 normal-weight people. The obese people had lower blood levels of this peptide compared to the normal-weight people. When both groups were given intravenous infusions of the peptide, they ate 30% fewer calories over the next 24 hours.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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To eat or not to eat -- how the gut talks to the brain
Article Abstract:
Hunger and satiety both involve gastrointestinal peptides that affect the brain. These peptides include insulin, leptin, ghrelin, cholecystokinin, peptide YY(sub 3-36), and alpha-melanocyte-stimulating hormone. Research on these peptides may lead to the development of drugs to treat obesity.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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