The future of IL-2 in HIV
Article Abstract:
The quality-of-life issue was discussed and in the ACTG 328 study, patients were randomized to receive highly active antiretroviral therapy (HAART) plus intermittent interleukin (IL) 2, by intravenous or subcutaneous routes. The subcutaneous administration of IL-2 showed a significant increase in quality of life over both intravenous delivery and HAART alone.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Interleukin-7 receptor expression on CD8 T-cells in downregulated by the HIV Tat Protein
Article Abstract:
The way in which HIV Tat protein downregulates cell surface expression of CD127 on human CD8 T-cells in a dose and time dependent manner is demonstrated. It is felt that Tat may play an important role in HIV-induced immune dysregulation and impaired cell-mediated immunity due to the apparent inhibition of cytotoxic activity by Tat.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
User Contributions:
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Upregulation of interferon-[alpha] and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior
Article Abstract:
A study distinguishes a relatively high expression of interferon-[alpha] (IFN[alpha]) and RANTES in HIV-1-infected versus low-risk control subjects. Induction of IFN[alpha] and RANTES expression in cervical mucosa could lead to protection of sexual HIV-1 transmission in subjects with a higher risk behavior.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The effects of repeated spectroscopic pressure measurements on fluorescence intensity in the cervix. Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid
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- Abstracts: Viruses and microRNAs. HIV-1 infection: fooling the gatekeeper. A new entry route for HIV
- Abstracts: Micronutrient supplementation increases CD4 count in HIV-infected individuals on highly active antiretroviral therapy: A prospective, double-blinded, placebo-controlled trial