Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs

Article Abstract:

Inflammation may actually help fetal lungs mature. In a study on pregnant sheep, those that received an injection of E. coli endotoxin gave birth to lambs with more mature lungs. Endotoxins are bacterial toxins that cause inflammation. The lung maturity seen in this study was greater than that achieved by giving pregnant animals and humans corticosteroids.

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The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep

Article Abstract:

Endotoxin injected into amniotic fluid along with corticosteroids taken by the mother may improve lung function in premature babies, according to a study in sheep. Endotoxin also prevents growth restriction caused by corticosteroids. Endotoxins are substances produced by bacteria.

Corticosteroids, Adrenocortical hormones

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Preterm lung function after retreatment with antenatal betamethasone in preterm lambs

Article Abstract:

Fetuses treated with betamethasone to improve lung function may not experience greater improvement with subsequent betamethasone treatments. Researchers compared the lung function of fetal sheep receiving one dose of betamethasone with that of fetuses receiving another dose administered six days later. Betamethasone treatment improved lung ventilation by almost 50% as well as doubled lung volume. Lung function after birth and during autopsy was not significantly different between the two groups, indicating that one betamethasone treatment is sufficient to improve lung function.

Care and treatment, Fetus, Drug therapy, Respiratory insufficiency, Betamethasone, Pediatric respiratory diseases, Pulmonary surfactant, Pulmonary surfactants, Respiratory insufficiency in children

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