The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type I

Article Abstract:

For patients who have tested positive for infection by the human immunodeficiency virus (HIV), it is of great importance that the progression of the infection and its associated disease states be monitored and predicted with accuracy. The predictive or prognostic value of certain changes in the pattern of blood cells and proteins in HIV-infected individuals is examined. Early in the course of HIV infection, most individuals experience a stimulation of the immune system that leads to an increased release in the blood of specific white cells known as CD8+T cells. Concomitant with this stimulation is the release of specific cell growth-promoting proteins and development of receptors for the HIV antigens on certain cells. As the infection progresses, other white blood cells, CD4+T or helper T cells, tend to fall in number. Loss of CD4+T cells is related to a decrease of the body's ability to provide cell-mediated immunity, and the individual becomes less able to fight infections. Changes of three cellular and five chemical markers of the AIDS infection in the blood of 400 homosexual and bisexual men known to be infected with HIV were studied. The study show that the absolute levels of CD4+T cells and specific other blood proteins (neopterin and beta-sub.2 microglobulin) are useful in predicting the progress of the HIV infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Physiological aspects, HIV (Viruses), HIV, Cellular immunity, Biological markers

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Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodes

Article Abstract:

Detailed assessments of T-lymphocyte subpopulations and comparison of blood and lymph nodes in HIV-1 infected and uninfected persons are performed. Multiple linear regression analysis reveals that CD38 expression node CD8(super +)T lymphocytes are the sole independent predictor for viremia.

Science & research, Risk factors, HIV infection, HIV infections, Lymph nodes, Regression analysis

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Elevated CD38 antigen expression on CD8+T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the multicenter AIDS cohort study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression

Article Abstract:

This study looked for immunological markers among patients who had been infected with AIDS for more than eight years. The value of a marker such as CD38 and CD8 is that it allows relatively reliable prognostication which helps in management of the disease.

Statistical Data Included, CD8 lymphocytes

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• Abstracts: The risk of Pneumocystis carinii pneumonia among men infected with human immunodeficiency virus type I. Survival from early, intermediate, and late stages of HIV infection

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