Infliximab and methotrexate in the treatment of rheumatoid arthritis
Article Abstract:
Intravenous infliximab may stop the progression of joint damage in patients with rheumatoid arthritis when used in combination with methotrexate. Infliximab is a monoclonal antibody that blocks the activity of tumor necrosis factor.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
Article Abstract:
An experimental drug called CTLA4Ig may benefit many patients with rheumatoid arthritis, especially those who do not respond to methotrexate. This was the conclusion of a study of 339 patients, all of whom were also taking methotrexate. CTLA4Ig was more effective than a placebo, or inactive substance. This drug prevents T cells from becoming activated.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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The rationale for the current boom in anti-TNFalpha treatment: is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Article Abstract:
Pharmaceutical companies are developing drugs that block the activity of tumor necrosis factor (TNF) to treat patients with rheumatoid arthritis. TNF is a protein produced by the body that causes inflammation.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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