Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage
Article Abstract:
The apolipoprotein E epsilon2 or epsilon4 genes appear to increase the risk of recurrent hemorrhage in patients with lobar intracerebral hemorrhage. Lobar intracerebral hemorrhage is a hemorrhage in the brain caused by amyloid deposits in blood vessels. In a study of 71 patients who had a lobar intracerebral hemorrhage, 19 had a recurrent hemorrhage. The two-year recurrence rate was 28% among carriers of the epsilon2 or epsilon4 gene compared to 10% among carriers of other apolipoprotein E genes.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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Lobar intracerebral hemorrhage
Article Abstract:
Genetic analysis can identify which patients are at risk for lobar hemorrhage and its recurrence. Lobar hemorrhage is a type of brain hemorrhage. It is sometimes caused by deposits of amyloid protein in the brain. A study found that stroke patients with the apolipoprotein E epsilon2 or epsilon4 gene had almost four times the risk of a recurrent lobar hemorrhage than those who didn't have these genes. These genes have also been implicated in Alzheimer's disease, which is also characterized by amyloid deposits in the brain.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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The risk of subarachnoid and intracerebral hemorrhages in blacks as compared with whites
Article Abstract:
Young and middle-aged blacks may have a higher risk of subarachnoid and intra-cerebral hemorrhages (brain hemorrhages) than whites. Stoke is a major cause of death among blacks, and almost half the individuals who die from strokes have subarachnoid and intra-cerebral hemorrhages. A study compared the number of subarachnoid and intra-cerebral hemorrhages in blacks to the number in whites during 1988 in the greater Cincinnati area. Among 171,718 blacks, 18 subarachnoid hemorrhages and 27 intra-cerebral hemorrhages occurred. Sixty-two subarachnoid hemorrhages and 159 intra-cerebral hemorrhages took place among 1,086,462 whites. The risk of subarachnoid hemorrhage was twice as high, and the risk of intra-cerebral hemorrhage was 1.4 times as high in blacks as in whites. In individuals less than 75 years old, the risk of subarachnoid hemorrhage was 2.3 times higher in blacks compared to whites. But after the age of 75, blacks had one-fourth the risk of whites for intra-cerebral hemorrhage. The number of deaths within 30 days from subarachnoid and intra-cerebral hemorrhages was approximately the same for both blacks and whites.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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