Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
Article Abstract:
The precise mechanism of action of Isoniazid, the most effective antituberculosis drug, is yet to be configured. A study conducted by using specialized linkage transduction to transfer a single point mutation allele (S94A) within the putative target gene inhA in Mycobacterium tuberculosis found that the inhA(S94A) was sufficient to confer clinically relevant levels of resistance to isonizad killing and inhibition of mycolic acid biosynthesis and establishes InhA as the primary target of isoniazid action in M. tuberculosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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The open book of infectious diseases
Article Abstract:
New antitubercular compounds belonging to chemical classes that are newly exploited along with more efficient methods to identify drug targets have produced exciting developments in antituberculosis antibiotics. The impact of new drugs, which are still in clinical trial stages, on the treatment of infectious diseases is discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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From magic bullets back to the Magic Mountain: The rise of extensively drug-resistant tuberculosis
Article Abstract:
An integrated approach is required for tackling the problem of extensively drug-resistant tuberculosis (XDR-TB) in high HIV prevalence settings. The World Health Organization's (WHO's) recommendations for controlling XDR-TB and also the development in research and development of the drugs for preventing TB are discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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