Treatment of acute myeloid leukaemia in a renal allograft recipient: implications of cyclosporin immunosuppressive treatment

Article Abstract:

Patients commonly develop resistance to drugs used to treat disease. A molecule known as P-glycoprotein is involved in resistance to vincristine and daunorubicin, drugs used to treat several cancers including acute myeloid leukemia (AML). However, there are other drugs, such as cyclosporin, that inhibit the activity of P-glycoprotein. Some of these drugs are being considered for use along with the chemotherapy. However, normal cells also express P-glycoprotein, and the inhibition of P-glycoprotein activity may cause increased toxicity in normal cells of the gastrointestinal tract, the lungs, and the kidneys. A case study is presented of a 61-year-old man who received a kidney transplant and was treated with the drug cyclosporin to suppress the immune system to prevent rejection of the kidney. The man later developed AML and was treated with a chemotherapy regimen that included daunorubicin. The patient's leukemia went into remission and there was no evidence that the patient suffered increased toxicity to normal tissue from the cyclosporin treatment. Therefore, inhibition of P-glycoprotein with drugs such as cyclosporin may be considered for use with chemotherapy for treatment of AML and other cancers of the blood cells. The patient did, however, develop a fatal bacterial infection due to immune system suppression. Drugs may be developed that inhibit P-glycoprotein, but do not cause suppression of the immune system. (Consumer Summary produced by Reliance Medical Information, Inc.)

Care and treatment, Evaluation, Prevention, Leukemia, Drug resistance, Cyclosporine, Cyclosporins

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In vivo and in vitro studies on anaplasma phagocytophilum infection of the myeloid cells of a patient with chronic myelogenous leukemia and human granulocytic ehrlichiosis

Article Abstract:

The occurrence of human granulocytic ehrlichiosis (HGE) in a patient with chronic myelogenous leukemia (CML) is studied, which suggest that anaplasma phagocytophilum preferentially infects mature granulocytes. It is found that the organism grew better in CML cells than in HL-60 cells and showed that the primary site of infection in HGE is the peripheral mature granulocytic population.

Science & research, Research, Chronic myeloid leukemia, Phagocytosis, Ehrlichiosis

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Acute myeloid leukaemia presenting as cholestatic hepatitis

Article Abstract:

A report of a rare case of a 40-year-old man with acute myeloid leukaemia presenting as jaundice, is discussed. Chemotherapy using acute myeloid leukaemia protocol resulted in complete resolution of the jaundice and complete molecular remission.

Cholestasis, Acute myelocytic leukemia, Jaundice, Obstructive

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