Treatment of oligohydramnios with maternal 1-deamino-(8-D-arginine) vasopressin-induced plasma hypoosmolality

Article Abstract:

Pregnancies with reduced amniotic fluid volume may be treated with a combination of oral water loading and an antidiuretic. Researchers treated five pregnant women with reduced amniotic fluid volume with oral water loading and intravenous 1-deamino-[8-D-arginine] vasopressin (dDAVP), an antidiuretic. Urine flow increased after oral water loading and before administration of dDAVP. Urine flow decreased after intravenous administration of dDAVP and stayed low for eight hours. The amniotic fluid index was significantly higher at the end of the eight hours, and remained higher for 24 hours. The amniotic fluid index did not increase in women receiving oral water loading alone. Levels of solid particles and of salt were reduced during the combination treatment.

Health aspects, Drug therapy

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1-deamino-(8-d-arginine) vasopressin-induced maternal plasma hypoosmolality increases ovine amniotic fluid volume

Article Abstract:

Treatment of pregnant mothers with an antidiuretic may correct the lack of amniotic fluid known as oligohydramnios. Researchers administered the antidiuretic vasopressin to pregnant sheep after they had been given lots of water to drink. Mothers experienced a decrease in plasma volume, and fetuses swallowed less fluid and excreted more urine, all of which raised the amount of amniotic fluid by 70% within two days. Vasopressin did not cause maternal blood pressure to drop. Instead maternal systolic pressure increased. Vasopressin was not found to cross the placenta. Red blood cell counts and systolic blood pressure were normal in the fetuses and no swelling was observed, indicating that the fetuses were well hydrated.

Measurement, Physiological aspects, Amniotic fluid

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Objective definition of shoulder dystocia: a prospective evaluation

Article Abstract:

Shoulder dystocia, the difficulty to deliver the fetal shoulder, may cause injury or death. An objective definition of shoulder dystocia includes higher birth weight, a lower Apgar score at one minute, and the risk of birth injury. Complicated and lengthy labor was also associated with shoulder dystocia, although medical records did not always reflect this detail.

Injuries, Prevention, Risk factors, Fetus, Dystocia, Labor, Complicated, Labor complications

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