Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Article Abstract:
Estrogen replacement therapy may not lower the risk of heart attack or death in postmenopausal women with coronary heart disease. Researchers randomly assigned 2,763 postmenopausal women with coronary disease to take estrogen plus medroxyprogesterone acetate or a placebo daily. After an average follow-up of 4.1 years, the rate of heart attack or death from coronary heart disease was similar in both groups. This occurred despite the fact that the women on hormone therapy had lower levels of LDL, or 'bad' cholesterol and higher levels of HDL, or 'good' cholesterol.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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High-density lipoprotein as a therapeutic target
Article Abstract:
The possibility that the normally believed high-density lipoprotein as a major cause of coronary heart disease could have therapeutic value is studied.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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