Turning neurogenesis up a notch
Article Abstract:
Scientists report that signaling through Notch, a single-pass transmembrane receptor activated by ligands on adjacent walls, may hold a key to the regulation of neurogenesis, including neurogenesis that occur after stroke. Experiments in a rat model indicated that activation of Notch could also stimulate neurogenesis and healing after stroke.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Article Abstract:
Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. An orthologous mouse model is presented that shows response to OPC31260 treatment with presentation of renal enlargement, marked inhibition of cystogenesis and protection of renal function.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Inhibition of renal cystic disease development and progression by a vasopressin V2receptor antagonist
Article Abstract:
Research shows that administration of the vasopressin V2 receptor antagonist, OPC31260, lowers renal cyclic AMP, arrests renal cystic disease development and either inhibits progression or regresses established disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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- Abstracts: Gene-environment interactions and the etiology of common complex disease. Trajectories of health for older adults over time: accounting fully for death
- Abstracts: Intravenous morphine and topical tetracaine for treatment of pain in preterm neonates undergoing central line placement
- Abstracts: IKK mediates ischemia-induced neuronal death. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells