Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Article Abstract:
A new function of Uncoupling Protien-2 (UCP-2), which was previously implicated in obesity, diabetes, inflammation and inhibition of cell death are described. It is found that UCP-2 reduces brain damage after experimental stroke and brain trauma, and alters mitochondrial release of Reactive Oxygen Species (ROS) and activation of caspase-3.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals
Article Abstract:
Research presented concerns the role of Nef proteins in the disease progression of AIDS, focusing on the relationship between Nef and the activation of p21-activated kinase. Findings suggest that Nef can block apoptosis or cell death in T cells through the induction of Bad phosphorylation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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