Use of computerized morphometric analyses of endometrial hyperplasias in the prediction of coexistent cancer
Article Abstract:
Morphometric analysis of cell nuclei may accurately diagnose cancer in tissue samples of overgrowths in the inner uterine wall. Researchers analyzed tissue samples from pathology department archives of 45 women with uterine wall tumors and of 10 women with uterine cancer. Twelve of the 45 women with uterine tumors were found to have cancer along with atypical tumor growth at the time of hysterectomy. Morphometric analysis of cell nuclei predicted uterine cancer from tissue samples in all of these cases. Age and other indicators did not predict cancer in these patients. Morphometric analysis involves calculating a 4-class score of degree of tumor growth and a D score of the density and volume of tumors. Morphometric analysis can assist in deciding among treatment options.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Guanylyl Cyclase C Messenger RNA Is a Biomarker for Recurrent Stage II Colorectal Cancer
Article Abstract:
Using the reverse transcriptase polymerase chain reaction (RT-PCR) technique to identify guanylyl cyclase C messenger RNA in lymph node biopsy samples may detect patients with a high risk of recurring colorectal cancer. Guanylyl cyclase C is produced by intestinal and colorectal cancer cells but not by other healthy tissues or tumors. Researchers used RT-PCR on lymph node tissue samples from 21 patients with recurring colorectal cancer despite surgical treatment and 11 patients with no cancer recurrence after surgery. Guanylyl cyclase C was found in all patients with a recurrence but none of those without a recurrence.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1999
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Endometrial cancer in polyps associated with tamoxifen use
Article Abstract:
Tamoxifen appears to be capable of turning some endometrial polyps cancerous. Most endometrial polyps, which occur inside the uterus, are benign. Of 15 women with endometrial cancer seen at Thomas Jefferson Hospital in Philadelphia, five had cancer only within an endometrial polyp. Microscopic examination of tissue samples revealed that in four of these women, the endometrium surrounding the polyp was not cancerous. All 15 patients had taken tamoxifen for two to five years. Tamoxifen is sometimes given to prevent recurring breast cancer in women.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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