VWF meets the ADAMTS family

Article Abstract:

Research presented concerns the genetic aspects of the rare and severe blood disorder known as thrombotic thrombocytopenic purpura, which is characterized by an increased activation of platelets. Research on the etiology and pathology of TTP suggests that mutations in the ADAMTS family of proteinases have the ability to cleave von Willebrand factor.

Thrombocytopenic purpura, Blood diseases, Hematologic diseases, Von Willebrand factor

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Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

Article Abstract:

Research indicates that in the progression of ovarian tumor, the Fanconi anemia gene FANCF undergoes methylation-demethylation leading to cisplatin resistance. The Fanconi anemia-BRCA pathway regulaes cisplatin sensitivity and it is disrupted in some ovarian tumor lines. Data indicate that cisplatin resistance is restored by FANCF complementation.

United Kingdom, Netherlands, Usage, Physiological aspects, Drug therapy, Ovarian cancer, Drug resistance, Cisplatin

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Connecting Fanconi anemia to BRCA1

Article Abstract:

Research presented concerns the hereditary disorder Fanconi anemia (FA), focusing on the molecular function of the genes associated with the disease. The genes FANCD2 and BRCA1 are discussed, along with the role FA plays increasing cancer susceptibility.

DNA damage, Proteins

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